Podosome rosettes precede vascular sprouts in tumour angiogenesis
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چکیده
منابع مشابه
FAK is required for the assembly of podosome rosettes
Podosomes are dynamic actin-enriched membrane structures that play an important role in invasive cell motility and extracellular matrix degradation. They are often found to assemble into large rosettelike structures in highly invasive cells. However, the mechanism of this assembly remains obscure. In this study, we identified focal adhesion kinase (FAK) as a key molecule necessary for assembly....
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* Corresponding author: Tel.: ++49 (0)711 68565036; Fax: ++49 (0)711 685; Email: [email protected] 1 Center Systems Biology, University of Stuttgart, Germany 2 OCCAM and Department of Computer Science, University of Oxford, United Kingdom 3 H. Lee Moffitt Cancer Center and Research Institute, Tampa, United States of America 4 Centre de Recerca Matemàtica, Campus de Bellaterra, Barcelona, Spain...
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In this review we summarize the current understanding of signal transduction downstream of vascular endothelial growth factor A (VEGFA) and its receptor VEGFR2, and the relationship between these signal transduction pathways and the hallmark responses of VEGFA, angiogenesis and vascular permeability. These physiological responses involve a number of effectors, including extracellular signal-reg...
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ژورنال
عنوان ژورنال: Nature Cell Biology
سال: 2014
ISSN: 1465-7392,1476-4679
DOI: 10.1038/ncb3044